Current Threat of Triclabendazole Resistance in Fasciola hepatica
نویسندگان
چکیده
منابع مشابه
Lack of reversion in triclabendazole-resistant Fasciola hepatica.
RESISTANCE to triclabendazole in field isolates of the liver fluke Fasciola hepatica in sheep was described for the first time by Overend and Bowen (1995) in Australia. In Europe, resistance of F hepatica in sheep to triclabendazole has been reported in Ireland (Lane 1998), Scotland (Mitchell and others 1998), Wales (Thomas and others 2000) and the Netherlands (Moll and others 2000). On the Dut...
متن کاملAn amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations.
Control of fasciolosis is threatened by the development of anthelmintic resistance. Enhanced triclabendazole (TCBZ) efflux by ABC transporters such as P-glycoprotein (Pgp) has been implicated in this process. A putative full length cDNA coding for a Pgp expressed in adult Fasciola hepatica has been constructed and used to design a primer set capable of amplifying a region encoding part of the s...
متن کاملApparent Triclabendazole-Resistant Human Fasciola hepatica Infection, the Netherlands
1. European Food Safety Authority. EFSA Panel on Animal Health and Welfare; scientifi c opinion on African swine fever. EFSA Journal. 2010;8:1556. http://dx.doi. org/10.2903/j.efsa.20101556 2. Sanchez-Botija C. Reservoirs of ASFV: a study of the ASFV in arthropods by means of the haemadsorption test. Bull Off Int Epizoot. 1963;60:895–9. 3. Boinas FS, Wilson AJ, Hutchings GH, Martins C, Dixon LJ...
متن کاملTriclabendazole Effect on Protease Enzyme Activity in the Excretory- Secretory Products of Fasciola hepatica in Vitro
BACKGROUND Fasciola hepatica is one of the most important helminthes parasites and triclabendazole (TCBZ) is routinely used for treatment of infected people and animals. Secreted protease enzymes by the F. hepatica plays a critical role in the invasion, migration, nutrition and the survival of parasite and are key targets for novel drugs and vaccines. The aim of study was to determine the prote...
متن کاملScreening anthelmintic resistance to triclabendazole in Fasciola hepatica isolated from sheep by means of an egg hatch assay
BACKGROUND In the present study, the detection of anthelmintic resistance to triclabendazole (TCBZ) in sheep infected by Fasciola hepatica was studied using an egg hatch assay (EHA). F. hepatica eggs were recovered from bile and faeces of infected animals by isolates with different grade of anthelmintic resistance to TCBZ: i) a resistant isolate (RT); ii) a susceptible isolate (ST); iii) natura...
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ژورنال
عنوان ژورنال: Trends in Parasitology
سال: 2016
ISSN: 1471-4922
DOI: 10.1016/j.pt.2016.03.002